MT-ND6 pseudogene 24 (MTND6P24)

MT-ND6 pseudogene 24 (MTND6P24) is annotated as a *pseudogene* of the mitochondrial gene MT-ND6, which encodes a subunit of Complex I (NADH:ubiquinone oxidoreductase) of the mitochondrial electron transport chain[1][2][3][5]. As a pseudogene, MTND6P24 does not encode a functional protein and has no known biological activity or role in disease, drug response, or cell signaling[1][3][5]. There is currently no evidence in the biomedical literature to support MTND6P24 as a receptor, enzyme, transporter, or any other class of therapeutic target. Is this entry correct as a therapeutic target? No. MTND6P24 is not considered a therapeutic target. It is a pseudogene, and there is no evidence for expression of a functional product, disease relevance, or druggability. Most structured drug discovery sources omit pseudogenes unless there is strong evidence of regulatory or non-coding function relevant to disease, which is not the case here[1][5]. Is there something wrong with this target? Yes. The entry for "MT-ND6 pseudogene 24" refers to a pseudogene rather than a functional receptor, enzyme, transporter, or other active protein. Unless there is new, specific literature showing non-coding or regulatory function, pseudogenes like MTND6P24 are not considered drug targets. The name is not misspelled, but the concept is inappropriate for typical therapeutic target lists[1][3][5]. Additional context: - The *MT-ND6* gene and its protein product are well-characterized and are associated with several mitochondrial diseases, but this does not apply to its pseudogenes[1][3][5]. - Functional MT-ND6 is involved in electron transfer and ATP synthesis in mitochondria; its loss or mutation causes optic neuropathy, myopathy, or Leigh syndrome, but these findings do not extend to pseudogenes[1][2][3][5][7]. Summary: MT-ND6 pseudogene 24 (MTND6P24) is a non-coding pseudogene with no known biological or therapeutic relevance. Its inclusion as a target is likely inappropriate except for specialized research on non-coding genomic elements. All established functional and therapeutic target information pertains to MT-ND6, not to its pseudogenes[1][3][5].

Other names

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6 pseudogene 24MTND6P24