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Target intelligence / Profile preview
Mechanistic Target of Rapamycin Complex 1 (mTORC1)
- Target
- mTORC1
- Molecular classification
- Multi-protein kinase complex, Kinase complex
01
Overview
mTORC1 is a central regulator of cell growth, metabolism, and proliferation. It is a multi-protein kinase complex that integrates signals from nutrients, energy status, growth factors, and stress to control anabolic processes. Activated at the lysosomal surface upon sufficient amino acid levels, it promotes protein synthesis, lipid biosynthesis, and other metabolic functions. mTORC1 is allosterically inhibited by rapamycin.
- Other names
- mTOR complex 1mammalian target of rapamycin complex 1
02
Mechanism of action
Allosteric inhibition of mTORC1 via FKBP12-rapamycin complex binding to the FRB domain of mTOR.
03
Biological functions
Protein synthesisLipid biosynthesisRibosome biogenesisAutophagy suppressionGlucose metabolism regulationCell growthMetabolismCell proliferation
04
Disease associations
CancerMetabolic diseasesObesityType 2 diabetesNeurodegenerative disordersAging-related pathologies
05
Safety considerations
Overactivation or deregulation of mTORC1 signaling can contribute to various diseases.Inhibition of mTORC1 can have broad effects on cellular metabolism.
06
Interacting drugs
Rapamycin
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