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mTOR signaling pathway

Molecular classification: Signaling pathway

Overview

The mTOR signaling pathway is a central regulator of cell growth, metabolism, proliferation, and survival. It integrates both intracellular and extracellular signals—including nutrients, growth factors, energy status, oxygen levels, and cellular stress—to coordinate anabolic (building) and catabolic (breakdown) processes in eukaryotic cells.

Other names: Mechanistic target of rapamycin pathwaymTOR pathway

Mechanism of action

Inhibition of mTORC1 activity

Biological functions

Cell growthCell proliferationMetabolic regulationProtein synthesisAutophagy regulationAngiogenesisCell survival

Disease associations

CancerObesityType II diabetes mellitusCardiovascular diseaseNeurodevelopmental disordersAutism spectrum disordersNeurodegenerative diseases

Interacting drugs

Rapamycin

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