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Target intelligence / Profile preview
mTORC1-Mediated Cholesterol Biosynthesis Pathway (N/A)
- Target
- N/A
- Molecular classification
- Signaling Pathway, Metabolic Pathway, Lipid Metabolism
01
Overview
The mTORC1-mediated cholesterol biosynthesis pathway describes the regulatory role of mTORC1 in controlling cellular cholesterol synthesis. mTORC1 activates SREBP-2, a master transcription factor for cholesterol synthesis genes, and regulates cholesterol trafficking to maintain low ER cholesterol levels, further sustaining SREBP-2 activity. This pathway is crucial for cell growth and function and dysregulation can contribute to various diseases.
- Other names
- mTORC1 Cholesterol RegulationmTORC1-SREBP2 PathwayCholesterol Biosynthesis Regulation by mTORC1mTORC1 Lipid Biosynthesis Pathway
02
Mechanism of action
Regulation of SREBP-2 activation and downstream cholesterol synthesis gene expression via mTORC1 signaling.
03
Biological functions
Cholesterol biosynthesisLipid homeostasisCell growthCell proliferationAutophagy regulationEndosomal traffickingGene transcription
04
Disease associations
Metabolic syndromeAtherosclerosisNeurodevelopmental disordersCancerCardiovascular disease
05
Safety considerations
Dysregulation can lead to altered lipid homeostasisPotential for metabolic side effectsImpact on cell growth and proliferation
06
Interacting drugs
Rapamycin
2 more in the full profile.
07
Biomarkers
SREBP-2 activityCholesterol levelsExpression of cholesterol biosynthesis enzymesmTORC1 activity
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