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Target intelligence / Profile preview
Mu Opiate Receptor (MOR)
- Target
- MOR
- Molecular classification
- G protein-coupled receptor, GPCR, Receptor
01
Overview
The mu opiate receptor, also known as the μ-opioid receptor (MOR), is a member of the opioid receptor family and plays a central role in mediating the effects of endogenous opioids and opioid drugs. It is primarily responsible for analgesia, euphoria, respiratory depression, miosis, decreased gastrointestinal motility, and dependence.
- Other names
- μ-opioid receptorMu receptorMOPMOPrOP3Opioid receptor mu type
02
Mechanism of action
Activation of the μ-opioid receptor leads to activation of inhibitory G proteins (Gi/Go), inhibition of adenylate cyclase activity, decreased cAMP levels, opening of potassium channels, and closing of calcium channels, resulting in reduced neuronal excitability.
03
Biological functions
AnalgesiaEuphoriaRespiratory depressionRegulation of gastrointestinal motilityModulation of pain perceptionReward pathways
04
Disease associations
PainAddictionRespiratory disordersGastrointestinal disorders
05
Safety considerations
Respiratory depressionAddictionConstipationToleranceOverdose
06
Interacting drugs
Morphine
4 more in the full profile.
07
Biomarkers
SNPs in OPRM1 (e.g., A118G)
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