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Target intelligence / Profile preview
Mucin-1 Antigen (MUC1)
- Target
- MUC1
- Molecular classification
- Single-pass type I transmembrane protein, Mucin
01
Overview
Mucin-1 (MUC1) is a high molecular weight, membrane-bound glycoprotein and a member of the mucin family. It acts as a protective barrier for epithelial surfaces. In cancer, MUC1 is frequently overexpressed with altered glycosylation patterns, contributing to tumor progression by promoting chemoresistance and metastasis. It serves as both a biomarker and a therapeutic target.
- Other names
- EpisialinPolymorphic Epithelial MucinPEMEpithelial Membrane AntigenEMAH23AgCA15-3MCA
02
Mechanism of action
Targeted therapies under investigation include vaccines and antibody-drug conjugates directed against tumor-associated forms.
03
Biological functions
Protective barrierLubricationHydrationAnti-adhesionIntracellular signaling
04
Disease associations
Cancer
05
Biomarkers
CA15-3 (circulating fragments)Overexpressed/aberrantly localized MUC1 in tumors
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