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Target intelligence / Profile preview
Mucin 1 (MUC1)
- Target
- MUC1
- Molecular classification
- Glycoprotein, Mucin, Type I transmembrane protein
01
Overview
Mucin 1 (MUC1) is a highly glycosylated type I transmembrane mucin protein overexpressed and aberrantly glycosylated in many epithelial cancers. It functions as a tumor-associated antigen presented to CD8+ cytotoxic T lymphocytes (CTLs) via MHC-I, leading to tumor cell lysis. MUC1 expressed on activated T cells also functions as a negative regulator of T cell proliferation. MUC1 is a target for cancer immunotherapy and vaccines.
- Other names
- EMACD227Tumor-associated epithelial mucin
02
Mechanism of action
CTL activation via presentation of MUC1-derived peptides on MHC-I; Modulation of T cell activation
03
Biological functions
Cell signalingImmune regulationAntigen presentationCell proliferation regulation
04
Disease associations
CancerAutoimmune diseases
05
Safety considerations
On-target, off-tumor toxicity due to MUC1 expression in normal tissuesImmune-related adverse events
06
Biomarkers
MUC1 expression levels in tumor tissueAntibody response to MUC1T cell response to MUC1 peptides
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