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Mucin 1 (cleaved form) (MUC1*)
- Target
- MUC1*
- Molecular classification
- Mucin, Type I transmembrane glycoprotein
01
Overview
Mucin 1 (MUC1) is a high molecular weight, type I transmembrane glycoprotein. After autoproteolytic cleavage at the GSVV motif within its SEA domain, it forms a heterodimeric complex (MUC1*) consisting of MUC1-N (extracellular domain) and MUC1-C (transmembrane and cytoplasmic tail). MUC1* plays roles in cell protection, signaling, and adhesion, particularly in epithelial cells. Aberrant expression and glycosylation of MUC1* are common in cancers, making it a valuable biomarker and therapeutic target.
- Other names
- MUC1 cleaved formMUC1*MUC1-N/MUC1-C heterodimer
02
Mechanism of action
Targeted by antibody-based therapies; inhibition of signaling pathways
03
Biological functions
Cell protectionLubricationCell signalingAdhesion modulationImmune modulationAntimicrobial defenseProliferationSurvival
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effects due to widespread epithelial expressionTumor-specific targeting is crucial to minimize toxicity
06
Biomarkers
MUC1 overexpressionMUC1 aberrant glycosylation
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