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Mucin-1 C-terminal Subunit
- Molecular classification
- Mucin, Transmembrane protein, Glycoprotein
01
Overview
Mucin-1 (MUC1) is a heterodimeric transmembrane glycoprotein. The C-terminal subunit (MUC1-C) remains membrane-bound after autoproteolytic cleavage and plays a role in signal transduction. It interacts with receptor tyrosine kinases and other signaling molecules, promoting cell growth and survival. MUC1-C is frequently overexpressed or aberrantly localized in carcinomas and is a target for therapeutic antibodies.
- Other names
- MUC1-CBeta subunitOncogenic transmembrane componentEMA (Epithelial Membrane Antigen)
02
Mechanism of action
Targeting MUC1-C with antibodies to inhibit its oncogenic signaling and promote tumor cell death.
03
Biological functions
Signal transductionCell growthCell survivalBarrier function
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effects due to MUC1 expression in normal tissues.Tumor-specific delivery strategies needed to minimize toxicity.
06
Biomarkers
MUC1-C overexpression in tumors
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