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Target intelligence / Profile preview
Mucin 1 Cell Surface Associated C-Terminal (MUC1-C)
- Target
- MUC1-C
- Molecular classification
- Type I transmembrane glycoprotein, Mucin
01
Overview
The C-terminal region of mucin 1 (MUC1-C) is a transmembrane subunit that plays a crucial role in oncogenesis by modulating intracellular signaling pathways. It is overexpressed in many carcinomas and contributes to epithelial-mesenchymal transition, cancer stem cell phenotype, and immune evasion. Its stable membrane association post-cleavage makes it an attractive target for antibody-based therapies.
- Other names
- MUC1 C-terminal subunitMucIN CMCUIN C
02
Mechanism of action
Monoclonal antibodies targeting MUC1-C epitopes to induce cell death or modulate signaling pathways.
03
Biological functions
Cell signaling modulationOncogenic transformationCell adhesionRegulation of gene expressionImmune evasion
04
Disease associations
CancerBreast cancerProstate cancerOvarian cancerPancreatic cancer
05
Safety considerations
Potential for off-target effects on normal epithelial cells expressing MUC1Development of resistance to MUC1-C targeted therapies
06
Biomarkers
MUC1-C expression levels in tumor tissueMUC1-C phosphorylation status
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