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Mucin-5AC (MUC5AC)
- Target
- MUC5AC
- Molecular classification
- Glycoprotein, Mucin
01
Overview
Mucin-5AC (MUC5AC) is a large, gel-forming glycoprotein that plays a critical role in protecting mucosal surfaces, particularly in the gastric and respiratory tracts. It forms a protective mucus barrier that traps pathogens and shields underlying tissues from damage. Overexpression or dysregulation of MUC5AC is implicated in airway diseases like asthma and COPD.
- Other names
- MUC5TBMleBmucin 5AColigomeric mucus/gel-forming
02
Mechanism of action
Modulation of MUC5AC expression via targeting transcription factors or coactivators like P300.
03
Biological functions
Mucosal protectionPathogen trappingMucus barrier formation
04
Disease associations
AsthmaChronic obstructive pulmonary disease (COPD)
05
Safety considerations
Inhibition of MUC5AC may compromise mucosal defense against infection
06
Biomarkers
MUC5AC levels in sputum or bronchoalveolar lavage fluid
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