Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Mucin 5B antisense RNA 1 (MUC5B-AS1)
- Target
- MUC5B-AS1
- Molecular classification
- Long non-coding RNA, Antisense RNA
01
Overview
Mucin 5B antisense RNA 1 (MUC5B-AS1) is a long non-coding RNA (lncRNA) transcribed from the antisense strand of the MUC5B gene locus on chromosome 11p15.5[2]. As a cytoplasmic lncRNA approximately 434 nucleotides in length, MUC5B-AS1 forms an RNA–RNA duplex with MUC5B mRNA, thereby increasing its stability and leading to enhanced MUC5B expression[2][1][3]. MUC5B-AS1 has been shown to function as an oncogenic lncRNA in lung adenocarcinoma, where it promotes cancer cell migration, invasion, and metastasis by upregulating MUC5B. The mutual stabilization between MUC5B-AS1 and MUC5B may serve as a novel therapeutic avenue for chemotherapeutic intervention, although MUC5B-AS1 itself is not a current direct therapeutic target and no drugs are known to specifically interact with it[3][2]. Elevated MUC5B-AS1 and MUC5B expression have prognostic significance in lung adenocarcinoma but are not directly tied to other major disease categories[3][2].
- Other names
- MUC5B-AS1MUC5B antisense RNA 1
02
Biological functions
Regulation of gene expressionmRNA stabilizationPromotion of cell migration and invasion (in cancer)
03
Disease associations
Cancer (specifically lung adenocarcinoma)
04
Biomarkers
MUC5B-AS1 expression (prognostic in lung adenocarcinoma)MUC5B expression (regulated by MUC5B-AS1)
Beyond the preview
Go deeper on Mucin 5B antisense RNA 1 (MUC5B-AS1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Mucin 5B antisense RNA 1 (MUC5B-AS1).