Mucin and epithelial cell surface protein (May be abbreviated as "MUC" for specific family members (e.g., MUC1, MUC4, MUC16), but there is no standardized abbreviation for the broad group "mucins and epithelial cell surface proteins")

Mucins are a diverse family of large, heavily glycosylated proteins expressed by epithelial tissues throughout the body. Cell surface mucins (such as MUC1, MUC4, MUC16) are transmembrane glycoproteins that coat the apical surface of epithelial cells, forming a protective barrier against pathogens and environmental insults. They modulate inflammation, regulate cell signaling pathways, and maintain epithelial integrity. Gel-forming mucins are secreted and constitute a major component of mucus. Dysregulation and overexpression of mucins, especially altered glycosylation patterns, are implicated in cancer, chronic inflammation, and susceptibility to infection. Cell surface mucins are important therapeutic targets and clinical biomarkers, though challenges remain due to their biochemical complexity and physiological importance.

Other names

Mucins (family: MUC1, MUC2, MUC4, MUC5AC, MUC6, MUC16, etc.)Cell surface mucinsTethered mucinsEpithelial mucinsAlternative names depend on the specific mucin; the generic term lacks precise aliases

Antibody-mediated targeting (direct cytotoxicity, immune cell recruitment). Inhibition of mucin-mediated cell signaling. Disruption of surface barrier to sensitize cells to therapy (e.g., improved drug delivery by altering mucin layer).