Mucin glycoprotein in the tear film

Mucin glycoproteins in the tear film are a diverse and essential group of heavily O-glycosylated proteins secreted by goblet cells (mainly MUC5AC, MUC2, MUC5B) and presented on the apical surface of corneal and conjunctival epithelia (mainly MUC1, MUC4, MUC16). These molecules maintain ocular surface hydration, prevent pathogen binding, provide lubrication to minimize mechanical damage from blinking, and regulate both barrier properties and cell signaling. Disruption or deficiency of tear film mucins is strongly associated with dry eye symptoms, increased surface friction, tear instability, and increased infection risk. While the mucin layer is essential for healthy vision and ocular surface defense, it is a complex mixture rather than a single pharmacological target, necessitating precise nomenclature for drug development and research.

Other names

Ocular surface mucinsTear film mucinsMucin family members in tear filmGlycocalyx mucins

Reduction of mucin disulfide bonding (NAC); Augmentation of mucin/tear secretion (experimental compounds, not approved); Restoration of mucin-like lubrication (recombinant lubricin/mucin analogs); Indirect stabilization or replenishment of tear film mucins (artificial tears with mucinomimetic properties)