Mucin glycoproteins and microbial biofilm matrices (Mucin: typically "MUC" plus gene number (e.g., MUC5B); microbial biofilm matrix: none standardized)

Mucin glycoproteins are large, heavily glycosylated proteins that form the primary structural component of mucus, providing lubrication and protection of mucosal surfaces in the respiratory, gastrointestinal, and other tracts[3][5]. They regulate microbial interactions by presenting glycans that serve as adhesion sites or signals and create a selective barrier to pathogen colonization and invasion. Microbial biofilm matrices are highly structured extracellular assemblies composed mainly of polysaccharides, proteins, extracellular DNA, and other macromolecules; they encase microbial communities, supporting structure, facilitating communication, and conferring resistance to antibiotics and host defenses[2][6][8]. Interactions between mucins and biofilm matrices are essential in both health (e.g., maintaining commensal colonization) and disease (e.g., chronic infections and inflammation), and are of therapeutic interest mainly for strategies to enhance mucosal protection or disrupt pathogenic biofilms. For more structured or specific drug-target information, it is necessary to refer to a specific mucin subtype (e.g., MUC5B, MUC2) or a specific biofilm matrix component (e.g., curli amyloid, cellulose, or individual exopolysaccharides)[1][2][3][5][8].

Other names

mucinsmucus proteinsgel-forming mucinstransmembrane mucinsextracellular polymeric substance (EPS)biofilm matrixextracellular matrix of biofilm

Disruption or degradation of matrix components (proteolysis, glycosidase, DNase activity). Synthetic or modified glycopolymers that mimic mucin’s ability to disperse or prevent biofilm maturation. Reduction of adhesion or signaling relevant to biofilm persistence.