Mucin-like protein 3 (MUCL3)

Mucin-like protein 3 (MUCL3) is a single-pass type I transmembrane protein with sequence features reminiscent of mucins, a family of glycoproteins characterized by repetitive regions rich in proline, threonine, and serine, leading to marked O-glycosylation[1][2]. Unlike classic mucins, MUCL3 is categorized as an orphan mucin due to lack of clear sequence homology with other mucins, likely emerging via lineage-specific evolutionary mechanisms[2]. The protein is predicted to be localized to the plasma membrane and cytoplasm[3], and may have regulatory roles in NF-kappaB signaling and cellular growth[3][4]. Disease associations include diffuse panbronchiolitis and spinocerebellar ataxia, but functional relevance in these conditions remains unclear[3]. MUCL3 is not currently recognized as a therapeutic target, and no drugs or validated mechanisms of drug action are known for this gene. There are also no documented uses as a biomarker or safety concerns. Its biological function and clinical significance remain to be elucidated[1][3][4].

Other names

Diffuse panbronchiolitis critical region protein 1C6orf37DPCR1PBLTbCX105N19.6