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Target intelligence / Profile preview
Mucosal Addressin Cell Adhesion Molecule 1 (MAdCAM-1)
- Target
- MAdCAM-1
- Molecular classification
- Cell Adhesion Molecule, Immunoglobulin Superfamily
01
Overview
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1) is an endothelial cell adhesion molecule primarily involved in directing lymphocyte trafficking to mucosal tissues, especially within the gastrointestinal tract. It interacts with integrins α4β7 and VLA-4, as well as L-selectin, to mediate leukocyte adhesion and rolling. MAdCAM-1 expression is upregulated during inflammation, and it is a therapeutic target for inflammatory bowel diseases such as Crohn's disease and ulcerative colitis.
- Other names
- addressin
02
Mechanism of action
Blocking α4β7/MAdCAM-1 interaction to reduce immune cell infiltration
03
Biological functions
Leukocyte HomingImmune SurveillanceMediation of Leukocyte Rolling and Adhesion
04
Disease associations
Inflammatory Bowel DiseaseCrohn's DiseaseUlcerative ColitisInflammation
05
Biomarkers
Soluble MAdCAM-1 in serum (marker of inflammation)
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