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Mucus in the Respiratory Tract
- Molecular classification
- Complex Mixture, Glycoproteins (Mucins), Water, Ions, Proteins/Enzymes
01
Overview
Mucus in the respiratory tract is a complex secretion produced by goblet cells and submucosal glands lining the airways. It traps inhaled particles, protects airway epithelial surfaces, and facilitates their removal via mucociliary clearance. The primary macromolecular components are mucins (MUC5AC and MUC5B), along with water, ions, and proteins. Expectorants are agents that enhance the expulsion of bronchial secretions by increasing hydration and/or stimulating ciliary activity. Dysfunction contributes to respiratory diseases through impaired gas exchange and infection risk.
- Other names
- Bronchial SecretionsAirway MucusPhlegmSputum
02
Mechanism of action
Expectorants (e.g., Guaifenesin) increase hydration of airway mucus and/or stimulate ciliary activity to facilitate expulsion of secretions.
03
Biological functions
Trapping inhaled particlesProtection of airway epitheliumHydration of airwaysMucociliary clearanceDefense against pathogens
04
Disease associations
AsthmaChronic BronchitisCOPDCystic FibrosisRespiratory Infections
05
Safety considerations
Mucus hypersecretion can impair gas exchange.Retained secretions increase the risk of infection.
06
Interacting drugs
Guaifenesin
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