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Target intelligence / Profile preview
Multi-drug Resistance Protein 2 (MRP2)
- Target
- MRP2
- Molecular classification
- Transporter, ABC transporter superfamily
01
Overview
MRP2 (ABCC2) is an ATP-binding cassette transporter primarily expressed on the apical membrane of hepatocytes, renal proximal tubular cells, enterocytes, and syncytiotrophoblasts. It functions as an efflux pump for a broad range of compounds, including conjugated organic anions, xenobiotics, and bilirubin. Mutations in ABCC2 cause Dubin-Johnson syndrome, and MRP2 contributes to multi-drug resistance in cancer.
- Other names
- ABCC2Canalicular multispecific organic anion transporter 1cMOATATP-binding cassette sub-family C member 2
02
Mechanism of action
Inhibition of MRP2-mediated efflux
03
Biological functions
DetoxificationChemoprotectionDrug metabolismBilirubin transportEfflux transport
04
Disease associations
Dubin-Johnson syndromeMulti-drug resistanceCancer
05
Safety considerations
Drug-drug interactions due to altered drug pharmacokineticsContribution to multi-drug resistance in cancer therapy
06
Interacting drugs
Probenecid
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