Multi-target

Multi-target" refers to the concept in drug development where one compound is intended or observed to interact with multiple biological targets, such as different receptors, enzymes, or proteins[1][10][8]. This approach is utilized for complex diseases that may require modulation of several pathways simultaneously, including cancer, neurodegenerative diseases, and cardiovascular disorders. Numerous databases, computational methods, and chemical libraries exist to facilitate the identification and design of such compounds[1][2][8], but "multi-target" is not a single target or molecule. As a term, it is too generic and non-specific to be indexed as a therapeutic target itself, and should instead be replaced by the specific names or abbreviations of the actual molecules or receptors under study. Key points: - "Multi-target" is a *strategy or property*, not a unique protein, gene, or receptor[1][2][8]. - This entry is **incorrect** for structured target databases and should be replaced with actual molecular names. - Various computational and experimental approaches (e.g., mt-QSAR, generative models, polypharmacology databases) are employed to discover and validate multi-target compounds, but they each reference specific pairs or groups of real molecular targets[1][8][10][2].

Other names

Polypharmacology targetMulti-target ligandDual-target molecule