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Target intelligence / Profile preview
Multiciliate differentiation and DNA synthesis associated cell cycle protein (MCIDAS)
- Target
- MCIDAS
- Molecular classification
- Transcription regulator, Transcriptional coactivator, Member of the Geminin superfamily
01
Overview
MCIDAS (Multiciliate differentiation and DNA synthesis associated cell cycle protein, also known as Multicilin) is a small, coiled-coil, nuclear protein that acts as a transcriptional coregulator essential for the differentiation of multiciliated epithelial cells. It functions by forming a complex with transcription factors E2F4/E2F5 and their cofactor Dp1 (the "EDM complex"), activating genes required for massive centriole biogenesis and the deuterosome pathway, which are critical for multiciliogenesis. MCIDAS is upstream of central regulators of ciliary motility such as CCNO and FOXJ1, and its loss-of-function mutations cause congenital disorders due to defective mucociliary clearance, including RGMC. MCIDAS does not directly bind DNA but coactivates transcription through protein-protein interactions with other transcription factors.
- Other names
- MulticilinMulticiliate differentiation and DNA synthesis-associated cell cycle proteinProtein IdasMCIMCINCILD42multiciliate cell differentiation 1McIdas proteinIDAS
02
Mechanism of action
Not applicable. No drugs directly target MCIDAS, so no mechanism of action for direct targeting
03
Biological functions
Regulates differentiation of multiciliated cells (epithelial cells with multiple motile cilia)Drives centriole biogenesis and assembly via the deuterosome pathwayActivates expression of genes involved in motile cilia formation (e.g., CCNO, FOXJ1, RFX2/RFX3, MYB)Forms a multiprotein (EDM) complex with E2F4/E2F5 and Dp1 to promote these effects
04
Disease associations
Genetic mutations cause reduced generation of multiple motile cilia (RGMC), a rare congenital mucociliary clearance disorder characterized by defective airway clearance, chronic respiratory infections, and sometimes hydrocephalusCongenital respiratory disease (phenotypically overlaps with primary ciliary dyskinesia, but mechanistically distinct)
05
Safety considerations
Not a therapeutic target; safety concerns relate to natural or inherited loss-of-function, which causes failure of mucociliary clearance and related disorders (not drug-related)
06
Biomarkers
Mutation analysis of MCIDAS as a genetic diagnostic marker for RGMC and related mucociliary disordersReduced number or absent multiciliated cells in airway and respiratory tissues can be indicative of MCIDAS dysfunction
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