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Target intelligence / Profile preview
Multidrug resistance-associated protein 1 (MRP1)
- Target
- MRP1
- Molecular classification
- ABC Transporter, Transporter
01
Overview
Multidrug resistance-associated protein 1 (MRP1), encoded by the ABCC1 gene, is an ATP-binding cassette (ABC) transporter that mediates the efflux of a wide range of substrates, including anticancer drugs, organic anions, and signaling molecules. Its primary role is to transport these substances across cellular membranes, contributing to drug resistance in cancer and influencing inflammatory and immune responses. It also plays a role in autosomal dominant sensorineural deafness.
- Other names
- ABCC1
02
Mechanism of action
ATP-dependent export of substrates from the cell
03
Biological functions
Drug effluxOrganic anion transportImmune responseCellular detoxificationLeukotriene transportcGAMP transport
04
Disease associations
Cancer chemoresistanceSensorineural deafnessInflammation
05
Safety considerations
Drug resistance developmentAltered drug pharmacokineticsPotential for drug-drug interactions due to altered efflux of multiple drugs
06
Interacting drugs
Vincristine
6 more in the full profile.
07
Biomarkers
ABCC1 expression level (predictive of chemoresistance)
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