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ATP-binding cassette sub-family C member 3 (ABCC3)
- Target
- ABCC3
- Molecular classification
- Transporter, ATP-binding cassette transporter, ABC transporter superfamily, MRP subfamily
01
Overview
ABCC3 is an ATP-binding cassette transporter involved in the efflux of various substrates, including drugs, toxicants, and endogenous compounds. It plays a role in multidrug resistance and is upregulated in liver pathology as a protective response. Its expression is regulated by transcription factors such as CAR, PXR, and Nrf2.
- Other names
- MRP3Multidrug resistance-associated protein 3Canalicular multispecific organic anion transporter 2CMOAT2MOAT-DMLP2cMOAT2
02
Mechanism of action
ATP-dependent transporter that binds and hydrolyzes ATP to actively transport substrates across cellular membranes, resulting in efflux of compounds from cells.
03
Biological functions
ATP-dependent transportEfflux of drugs and toxicantsTransport of glucuronide conjugatesTransport of glutathione conjugatesTransport of bile salts
04
Disease associations
Multidrug resistanceCancerLiver diseasesCholestasis
05
Safety considerations
Drug resistancePotential for drug-drug interactions
06
Interacting drugs
Promethazine
3 more in the full profile.
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