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Target intelligence / Profile preview
Multidrug Resistance-Associated Protein 4 (MRP4)
- Target
- MRP4
- Molecular classification
- ABC transporter superfamily, ATP-binding cassette transporter, Transporter
01
Overview
Multidrug resistance-associated protein 4 (MRP4), also known as ABCC4, is an ATP-binding cassette transporter that mediates the efflux of a wide range of endogenous and exogenous organic anionic compounds across cellular membranes. It plays a significant role in drug resistance, cancer biology, platelet function, and immune cell migration. MRP4 regulates intracellular cyclic nucleotide levels and is involved in cellular protection mechanisms. It is considered a promising target for modulating drug resistance in cancer therapy.
- Other names
- ABCC4ATP-binding cassette sub-family C member 4Multi-specific organic anion transporter BMOAT-B
02
Mechanism of action
ATP-dependent efflux transport of various organic anions and drugs; modulation of intracellular cyclic nucleotide levels
03
Biological functions
Efflux transportDrug resistance modulationRegulation of cyclic nucleotide levelsRegulation of platelet activationImmune cell migrationCellular protectionExtracellular signaling
04
Disease associations
CancerDrug resistanceAcute myeloid leukemia (AML)Peritoneal endometriosisCardiovascular diseaseThrombosis
05
Safety considerations
Inhibition affects both drug disposition/resistance profiles and physiological processes involving cyclic nucleotides/prostaglandinsPotential for off-target effects due to broad substrate specificity
06
Interacting drugs
Irinotecan
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