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Multidrug Resistance Pathway
- Molecular classification
- Pathway
01
Overview
The multidrug resistance pathway encompasses diverse molecular strategies enabling cells—especially tumor cells—to evade the effects of multiple therapeutic agents through mechanisms such as increased drug efflux via ABC transporters like P‑glycoprotein/MDR1. This remains a critical target for research into overcoming treatment failures in both oncology and infectious disease settings.
- Other names
- MDR Pathway
02
Mechanism of action
Multiple mechanisms including drug efflux, drug inactivation, target modification, and enhanced DNA repair.
03
Biological functions
Drug resistanceCell survivalEfflux of therapeutic agents
04
Disease associations
CancerBacterial infectionsInfectious disease
05
Safety considerations
Toxicity of efflux pump inhibitorsLack of clinical efficacy of anti-MDR agents
06
Interacting drugs
Chemotherapeutic agents
3 more in the full profile.
07
Biomarkers
P-glycoprotein (P-gp) expression levels
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