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Target intelligence / Profile preview
Multidrug Resistance Protein 1 (MDR1)
- Target
- MDR1
- Molecular classification
- Transporter, ATP-binding cassette transporter, ABC transporter
01
Overview
Multidrug resistance protein 1 (MDR1/P-glycoprotein/ABCB1) is an essential efflux pump responsible for protecting tissues from toxins but also mediates clinically significant drug resistance—especially during cancer treatment—by reducing intracellular accumulation through active export powered by ATP hydrolysis.
- Other names
- P-glycoproteinP-gpPermeability glycoproteinATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243
02
Mechanism of action
ATP-dependent efflux of a broad range of substrates from the cell, decreasing intracellular drug concentrations.
03
Biological functions
Efflux pumpDrug transportXenobiotic transportCell protection
04
Disease associations
Multidrug resistance in cancerPharmacokinetics & Drug InteractionsGenetic Variants & Animal Health
05
Safety considerations
Toxicity of P-gp inhibitorsCompensatory mechanisms within tumorsIncreased drug bioavailability and toxicity due to P-gp inhibitionIncreased sensitivity to medications in animals with MDR1 mutations
06
Interacting drugs
Chemotherapeutic agents
2 more in the full profile.
07
Biomarkers
MDR1/P-gp expression levels in tumor cells
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