Multimerin-2 (MMRN2)

Multimerin-2 (MMRN2) is an extracellular matrix glycoprotein predominantly expressed by endothelial cells, belonging to the EMILIN protein family. It directly interacts with cell-surface CTLD group 14 receptors (CLEC14A, CD93, CD248), orchestrating vessel formation, angiogenesis, and vascular stability through regulation of endothelial cell adhesion, migration, and proliferation. MMRN2 competes for key angiogenic signals by acting as a transforming growth factor beta antagonist and binding vascular endothelial growth factor (VEGFA), limiting its availability and modulating the VEGF-A/VEGFR2 pathway. Aberrant expression or proteolytic processing of MMRN2 is implicated in defective vessel maturation, increased vascular permeability, and compromised drug delivery in various cancers. These functions establish MMRN2 as a mechanistic biomarker and emerging therapeutic target in oncology and vascular biology.

Other names

EMILIN3Elastin microfibril interfacer 3EndoGlyx-1FLJ13465EMILIN-3EndoGlyx-1 p125/p140 subunitEMILIN-like protein EndoGlyx-1elastin microfibril interface located protein 3

Inhibition of MMRN2–CLEC14A binding to block tumor angiogenesis. Peptide fragments of MMRN2 competitively inhibit endothelial receptor binding, reducing vessel sprouting and tumor growth.