Multiple antioxidant and inflammatory pathway proteins

This term refers to the collective set of proteins and pathways regulating cellular responses to oxidative stress and inflammation. Notable members include antioxidant enzymes, transcription factors (e.g., Nrf2, NF-κB), inflammatory mediators (cytokines, chemokines), receptors (Toll-like receptors), signaling kinases (MAPKs), and molecular complexes such as the NLRP3 inflammasome. These entities orchestrate cellular defense, repair, immune responses, and pathological processes in chronic disease. The group is central to the balance of health and disease, mediating processes involved in inflammation, oxidative damage, cell survival, apoptosis, immune modulation, and tissue repair. However, "multiple antioxidant and inflammatory pathway proteins" is not a defined therapeutic target; instead, it represents numerous individual, sometimes interdependent, targets whose roles span diverse biological and pathological functions.

Other names

redox signaling proteinsinflammatory mediatorsstress response proteinsantioxidant enzymes

ROS scavenging and reduction (antioxidant enzymes, SOD mimetics); Inhibition of inflammatory signaling (NF-κB inhibition, NLRP3 inhibition); Modulation of gene expression for defense or resolution (Nrf2 activation, MAPK pathway modulation); Blocking cytokine signaling (anti-TNF therapies, IL-1 blockers); Reducing production of inflammatory mediators (COX-2 inhibition)