Multiple bacterial surface antigens (Pasteurella multocida, Escherichia coli, Trueperella pyogenes, and Fusobacterium necrophorum)

Multiple bacterial surface antigens on Pasteurella multocida, Escherichia coli, Trueperella pyogenes, and Fusobacterium necrophorum represent a composite target profile for veterinary biologicals. These antigens include outer membrane proteins, lipopolysaccharides, and adhesins that are essential for the virulence and survival of these pathogens in livestock [1, 4]. Pasteurella multocida and Escherichia coli are major causes of respiratory and enteric diseases, while Trueperella pyogenes (formerly Arcanobacterium pyogenes) and Fusobacterium necrophorum are primarily associated with pyogenic infections and liver abscesses [2, 3]. Therapeutic strategies targeting these antigens, such as polyvalent antisera (e.g., Poly-Serum), provide passive immunity by delivering antibodies that facilitate bacterial opsonization and neutralization [5]. This approach is particularly relevant in treating complex, polymicrobial conditions like Bovine Respiratory Disease and liver abscess complexes where multiple pathogens contribute to the pathology. Effective targeting of these surface molecules helps reduce bacterial load and mitigates the severity of clinical disease in affected animals [1, 5].

Other names

Bacterial surface antigensPolyvalent bacterial antigensArcanobacterium pyogenes antigensBRD complex antigensShipping fever antigens

Passive or active immunization targeting surface antigens to promote opsonization, neutralization of toxins, and complement-mediated lysis of the specified bacterial pathogens [5].