Multiple Bacterial Targets (N/A)

The strategy of designing or using antibacterial agents that act on more than one molecular target within bacterial cells. This approach is increasingly important in combating antibiotic resistance, as drugs with multiple targets are less likely to be rendered ineffective by single-point mutations or resistance mechanisms. Targets include cell wall synthesis, protein synthesis, DNA replication, and membrane integrity. Multitargeting can be achieved through single molecules or combination therapies.

Other names

Multitarget Antibacterial StrategyPolypharmacology in AntibioticsMulti-Action Antibiotics

Inhibition of distinct enzymes from separate metabolic pathways; disruption of structural components; interference with genetic material; induction of multiple stress responses.