Multiple C2 domain and transmembrane region protein 2 (MCTP2)

Multiple C2 domain and transmembrane region protein 2 (MCTP2) is an evolutionarily conserved, membrane-associated protein characterized by three N-terminal C2 domains and two C-terminal transmembrane regions[5][1]. MCTP2 localizes to specialized endoplasmic reticulum (ER) subdomains and is involved in organelle contact site formation, particularly with lipid droplets (LDs), peroxisomes, endosomes, and mitochondria[1]. The C2 domains bind calcium and participate in the regulation of LD size and biogenesis as well as ER–organelle tethering, while the transmembrane regions shape ER membrane morphology[1]. Functionally, MCTP2 is implicated in the calcium-dependent regulation of membrane processes but displays distinct properties from classical C2-domain proteins, with high-affinity calcium binding but atypical phospholipid interaction[5]. Pathologically, MCTP2 has been identified as a tumor progression factor and biomarker in oral squamous cell carcinoma (OSCC), promoting migration, invasion, and EMT processes[2]. However, it is not currently established as a classical therapeutic target (such as a receptor, enzyme, or transporter), and there are no known drugs or mechanism-of-action data specific to MCTP2 inhibition or modulation.

Other names

Multiple C2 and transmembrane domain-containing protein 2FLJ11175FLJ33303multiple C2 domains, transmembrane 2multiple C2-domains with two transmembrane regions 2