Multiple cell-surface receptors and extracellular matrix components engaged by peripheral blood mononuclear stem cells

The term "Multiple cell-surface receptors and extracellular matrix components engaged by peripheral blood mononuclear stem cells" refers to the complex molecular network that facilitates the adhesion, homing, and migration of stem cells from the blood into tissues. This process is mediated by a variety of cell-surface receptors, including integrins (e.g., VLA-4, LFA-1), selectins (e.g., L-selectin), and chemokine receptors (notably CXCR4), which interact with specific ligands in the extracellular matrix (ECM) such as fibronectin, laminin, and hyaluronic acid (Source: PubMed, PMID: 15683471). These interactions are essential for the recruitment of peripheral blood mononuclear stem cells (PBMSCs) to sites of tissue injury or to the bone marrow niche during hematopoiesis. In clinical contexts, this system is a major focus for regenerative medicine and hematology, as the mobilization of these cells is required for stem cell transplants (Source: Blood, PMID: 19380869). Therapeutic agents like Plerixafor (a CXCR4 antagonist) and G-CSF are used to disrupt these interactions to release stem cells into the peripheral blood for collection. Conversely, inhibitors of specific integrins, such as Natalizumab, are used to prevent the pathological migration of mononuclear cells into the central nervous system in diseases like multiple sclerosis (Source: Nature Reviews Drug Discovery, PMID: 15990888). Because this entry describes a broad functional pathway involving numerous distinct proteins, it is classified as a biological process rather than a single, discrete therapeutic target.

Other names

Stem cell homing pathwayPBMC-ECM adhesion networkMononuclear cell trafficking systemStem cell-niche interaction complex

Modulation of stem cell trafficking through the competitive inhibition or activation of specific adhesion receptors and chemokine signaling pathways.