Multiple cell-surface receptors on immune and tissue cells

The target 'Multiple cell-surface receptors on immune and tissue cells' is a collective designation for a broad array of surface proteins, including Fc receptors, various clusters of differentiation (CD) antigens, and major histocompatibility complex (MHC) proteins (Source: PubMed, PMID: 23237559). This designation is typically used to describe the multi-target interaction profile of polyclonal antibody therapies such as Intravenous Immunoglobulin (IVIG) and Antithymocyte Globulin (ATG) (Source: DrugBank, DB00097). These agents exert their therapeutic effects by simultaneously engaging numerous receptors on leukocytes and other tissue-resident cells, thereby modulating complex immune pathways rather than a single signaling axis. This approach is particularly effective in treating systemic autoimmune disorders, primary immunodeficiencies, and preventing organ transplant rejection, where the underlying pathology involves multiple redundant pathways. However, the lack of molecular specificity inherent in targeting multiple receptors can lead to significant safety challenges, including broad immunosuppression and systemic infusion reactions (Source: StatPearls, NBK537331).

Other names

Cell surface receptorsImmune cell surface antigensPolyclonal antibody targetsMulti-receptor target profile

Modulation of immune response through the simultaneous binding and neutralization of multiple cell surface receptors and soluble factors, leading to altered signaling and cell fate.