Multiple cellular and extracellular matrix components

Multiple cellular and extracellular matrix components refers to a broad, non-specific grouping of biological structures that provide mechanical and biochemical support to tissues (Source: NCBI Bookshelf, "The Extracellular Matrix", 2002). This category encompasses a diverse array of molecules, including structural proteins like collagen and elastin, adhesive glycoproteins such as fibronectin and laminin, and various proteoglycans (Source: Nature Reviews Molecular Cell Biology, "The extracellular matrix at a glance", 2014). In a therapeutic context, this term is typically used for drugs that act on the tissue environment as a whole rather than a single molecular receptor. For example, enzymes like Collagenase clostridium histolyticum are used to degrade collagen fibers to treat Dupuytren's contracture, while hyaluronidase is used to increase tissue permeability for drug delivery (Source: FDA Label, Xiaflex, 2010; StatPearls, "Hyaluronidase", 2023). Because this 'target' represents a complex mixture of components, it is generally considered a descriptive classification rather than a specific, druggable target in modern precision medicine.

Other names

Extracellular matrixECM componentsCellular and matrix structural elementsConnective tissue components

Enzymatic degradation or physical-chemical modification of various structural proteins (e.g., collagen, elastin) and carbohydrate complexes (e.g., hyaluronan) within the cellular environment and the surrounding matrix.