Multiple cellular pathways via secreted PBMC factors

Multiple cellular pathways via secreted PBMC factors refers to the collective signaling influence of the secretome derived from peripheral blood mononuclear cells (PBMCs). This is not a single molecular target but a therapeutic concept where a cocktail of cytokines, chemokines, and growth factors acts paracrinely to modulate diverse biological processes (Ankersmit et al., 2009, PubMed: 19344751). These factors are known to influence pathways related to angiogenesis, inflammation, and tissue remodeling, making them relevant in regenerative medicine (Laggner et al., 2009, PubMed: 19737414). For instance, the apoptotic PBMC secretome (APOSEC) has been investigated for its ability to reduce infarct size in cardiovascular models and promote healing in chronic wounds (ClinicalTrials.gov, NCT04277598). Because it involves a heterogeneous mixture of proteins affecting numerous receptors, it is classified as a multi-target physiological process rather than a discrete drug target. Its therapeutic application relies on the synergistic effect of these secreted factors to restore homeostasis in damaged tissues and modulate the local microenvironment.

Other names

PBMC secretomePeripheral blood mononuclear cell secretomeApoptotic PBMC secretomeAPOSECPBMC-derived factors

Modulation of multiple intracellular signaling cascades (e.g., MAPK, PI3K/Akt) through the paracrine action of a complex mixture of cytokines, chemokines, and growth factors.