Multiple CNS-related targets

The term Multiple CNS-related targets does not refer to a single biological molecule, receptor, or enzyme, but rather serves as a collective descriptor for a variety of distinct proteins within the central nervous system (CNS) that are simultaneously modulated by certain drugs. This phenomenon, known as polypharmacology, is particularly common in the treatment of complex neurological and psychiatric conditions such as schizophrenia, depression, and Alzheimer's disease, where a single agent may interact with multiple G protein-coupled receptors (GPCRs), ion channels, and transporters. For example, atypical antipsychotics often target a broad array of dopamine (D2) and serotonin (5-HT2A) receptors to achieve therapeutic efficacy while managing side effects. Because this entry represents a category rather than a specific, well-defined molecular entity, it is considered an incorrect or overly broad target designation for structured pharmacological data entry. Precise identification of the individual proteins involved (e.g., Dopamine D2 receptor, Serotonin 2A receptor, Acetylcholinesterase) is required for accurate target annotation and drug development analysis.

Other names

Multi-target CNS agentsPolypharmacological CNS targetsNon-specific CNS targets

Not applicable as this refers to a collective group of distinct biological entities rather than a single molecular target.