Multiple Coagulation Factor Deficiencies (MCFDs)

Multiple coagulation factor deficiencies (MCFDs) are rare inherited bleeding disorders characterized by the simultaneous deficiency or dysfunction of two or more blood coagulation factors. These factors are essential proteins involved in the coagulation cascade, which leads to blood clot formation. MCFDs can arise from coincidental inheritance of single-factor deficiencies, single-gene defects affecting multiple factors, or chromosomal deletions. Diagnosis involves clotting assays and molecular genetic testing. Treatment typically involves replacement therapy with plasma-derived or recombinant coagulation factors.

Other names

Familial Multiple Coagulation Factor DeficienciesFMCFDsCombined coagulation factor deficiency

Replacement of deficient coagulation factors, modulation of coagulation pathways (indirectly)