Multiple EGF-like domains protein 9 (MEGF9)

Multiple EGF-like domains protein 9 (MEGF9) is a single-pass transmembrane glycoprotein featuring five EGF-like domains that are highly homologous to those found in the laminin family. MEGF9 is expressed predominantly in the central and peripheral nervous system, with additional expression in skin, tongue papillae, and gastrointestinal tract. The protein contains an N-terminal region rich in O-glycosylation sites, followed by EGF-like motifs, a short transmembrane region, and a highly conserved intracellular tail with potential phosphorylation sites. The physiological role of MEGF9 is not fully elucidated, but it may be involved in neural and epithelial differentiation, cell–cell and cell–matrix adhesion, and guidance or signaling during development. MEGF9 is considered a putative receptor based on its structure and tissue localization; homologous domains to laminins suggest possible involvement in basement membrane interactions. Structural features include an N-terminal O-glycosylation region, five EGF-like domains, a transmembrane segment, and a short intracellular domain. It is expressed in the nervous system (neurons, glial cells), skin, and epithelial tissues. No established drugs, biomarkers, or specific disease mechanisms have been reported for MEGF9. Aliases are well-documented; no incorrect or obsolete entries are present. Research into biological and disease roles is ongoing, primarily in basic and developmental biology.

Other names

EGFL5KIAA0818Multiple epidermal growth factor-like domains protein 9EGF-like protein 5UNQ671/PRO1305Epidermal growth factor-like protein 5

Not established; mechanisms may involve modulation of cell–cell adhesion, basement membrane interactions, and signal transduction via phosphorylation, but no drugs are known to target MEGF9 directly