Multiple endogenous antigens and Fc gamma receptors

Multiple endogenous antigens and Fc gamma receptors represent the broad therapeutic target profile of Intravenous Immunoglobulin (IVIG) and Subcutaneous Immunoglobulin (SCIG) (Nature Reviews Immunology, 2013). This target complex is not a single molecular entity but a diverse set of circulating and cell-surface molecules that mediate the immunomodulatory effects of polyclonal IgG (Journal of Clinical Immunology, 2015). The 'endogenous antigens' include pathogenic autoantibodies, inflammatory cytokines, and complement fragments, which are neutralized or cleared through the action of the diverse antibody repertoire present in IVIG (Frontiers in Immunology, 2018). The}

Other names

IVIG targetsEndogenous antigens and Fc receptorsPolyclonal IgG targetsFc gamma receptors and autoantibodies

The mechanism of action involves a pleiotropic effect including the neutralization of pathogenic autoantibodies and inflammatory cytokines, competitive blockade of activating Fc gamma receptors (FcγRI, FcγRIIA, FcγRIIIA) on myeloid cells, upregulation of the inhibitory receptor FcγRIIB, and saturation of the neonatal Fc receptor (FcRn) to accelerate the catabolism of endogenous IgG.