Multiple endogenous mRNAs with miR-216a seed matches

Multiple endogenous mRNAs with miR-216a seed matches refers to the collective ensemble of messenger RNA (mRNA) transcripts that are post-transcriptionally regulated by microRNA-216a (miR-216a). miR-216a is a highly conserved, pancreas-specific microRNA that plays a critical role in maintaining cellular homeostasis and modulating signaling pathways by binding to complementary seed sequences in the 3' untranslated regions (UTRs) of target mRNAs (PubMed: 21835060). This binding typically results in the degradation of the mRNA or the inhibition of its translation into protein via the RNA-induced silencing complex (RISC). Key validated targets within this group include PTEN, which regulates the PI3K/Akt pathway, and SMAD7, a negative regulator of TGF-beta signaling (PubMed: 25135801, PubMed: 24631445). In diseases such as pancreatic cancer, miR-216a often acts as a tumor suppressor by targeting oncogenes like YBX1, whereas in kidney disease, its upregulation can contribute to fibrosis by silencing protective factors. Therapeutic strategies involve using miR-216a mimics to restore its suppressive function in cancer or antagomirs to block its activity in fibrotic conditions. Consequently, this target represents a complex regulatory network rather than a single molecular entity.

Other names

miR-216a targetomemiR-216a-5p target genesmiR-216a-3p target genesMicroRNA-216a regulated transcripts

MicroRNA-mediated gene silencing via seed-sequence complementarity to the 3' UTR of target mRNAs, leading to mRNA cleavage or translational inhibition.