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Target intelligence / Profile preview
Multiple endogenous ocular surface receptors
- Molecular classification
- G protein-coupled receptor, Ion channel, Receptor
01
Overview
- Other names
- Ocular surface receptorsEndogenous tear film receptorsTrigeminal parasympathetic pathway receptors
02
Mechanism of action
Activation of multiple receptor subtypes (muscarinic, purinergic, adrenergic) via endogenous neurotransmitter release to stimulate the production of aqueous, mucin, and lipid components of the tear film.
03
Biological functions
Tear productionHomeostasisSignal transductionSecretory regulation
04
Disease associations
Dry eye diseaseOcular surface disorderInflammation
05
Safety considerations
Sneezing (with nasal administration)CoughThroat irritationInstillation site pain
06
Interacting drugs
Varenicline (Tyrvaya)
3 more in the full profile.
07
Biomarkers
Tear break-up time (TBUT)Schirmer scoreCorneal staining score
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