Multiple endogenous plasma proteins and physiologic partners

Multiple endogenous plasma proteins and physiologic partners is a collective term used in pharmacological databases to describe the broad array of proteins found in human plasma that interact with certain therapeutic agents [1]. This category primarily encompasses high-abundance proteins such as albumin, which maintains approximately 80% of colloid osmotic pressure and transports various hormones and drugs, as well as immunoglobulins that provide passive immunity [2, 3]. Therapies associated with this designation are typically plasma-derived or recombinant products used for replacement or supplementation in conditions like hypovolemia, cirrhosis, or primary immunodeficiency [1, 4]. Because this term represents a complex physiological environment rather than a single molecular entity like a specific receptor or enzyme, it is often used when a drug's mechanism involves pleiotropic interactions across the plasma proteome [1, 5]. Consequently, it is considered a non-specific target category rather than a distinct therapeutic target. Citations: [1] DrugBank Online, Albumin human (DB00062); [2] StatPearls, Physiology, Albumin; [3] DrugBank Online, Immune globulin human (DB00028); [4] NCBI, Functions of Plasma Proteins; [5] Anderson & Anderson (2002), Molecular & Cellular Proteomics.

Other names

Plasma proteinsSerum proteinsBlood proteinsEndogenous plasma proteomePhysiologic plasma partners

Replacement of deficient plasma components, maintenance of oncotic pressure, and immunomodulation through passive antibody transfer [1, 2, 3].