Multiple endogenous receptors for secreted MSC factors

Multiple endogenous receptors for secreted MSC factors is a collective term describing the various molecular targets on host cells that respond to the paracrine signaling of Mesenchymal Stem Cells (MSCs). Rather than acting through a single pathway, MSCs release a broad array of bioactive molecules known as the secretome, including Transforming Growth Factor-beta (TGF-β), Interleukin-10 (IL-10), Prostaglandin E2 (PGE2), and Vascular Endothelial Growth Factor (VEGF). These factors bind to their respective cognate receptors, such as TGF-beta receptors, IL-10 receptors, and EP receptors, on target cells like T-lymphocytes, macrophages, and endothelial cells. This coordinated interaction triggers signaling cascades that suppress overactive immune responses, reduce inflammation, and stimulate endogenous tissue regeneration. Consequently, these receptors serve as the functional targets for MSC-based cellular therapies in treating complex inflammatory and degenerative conditions, including Graft-versus-Host Disease (GvHD) and perianal fistulas in Crohn's disease.

Other names

MSC secretome receptorsMesenchymal stem cell paracrine targetsEndogenous receptors for MSC-derived factorsMSC-derived secretome targets

Mesenchymal stem cells (MSCs) exert therapeutic effects by secreting a complex secretome of cytokines, growth factors, and lipid mediators that bind to specific endogenous receptors on host immune and parenchymal cells to modulate inflammation and promote repair.