Multiple endogenous receptors indirectly modulated via MSC paracrine factors

Multiple endogenous receptors indirectly modulated via MSC paracrine factors refers to the diverse set of host cell signaling proteins that respond to the secretome of Mesenchymal Stem Cells (MSCs). MSCs are increasingly recognized for their role as "injury drugstores," sensing the local environment and releasing a complex mixture of cytokines, growth factors, and extracellular vesicles rather than primarily differentiating into new tissue (Caplan & Correa, 2011). These secreted factors, such as TGF-β, IL-10, VEGF, and HGF, bind to their respective receptors on immune cells, endothelial cells, and fibroblasts to exert anti-inflammatory, pro-angiogenic, and anti-apoptotic effects (Galipeau & Sensébé, 2018). For instance, MSC-derived PGE2 and IDO are critical for modulating T-cell and macrophage activity via their specific receptors, which is a key mechanism in treating graft-versus-host disease (Pittenger et al., 2019). Because this term encompasses a wide range of distinct molecular targets across multiple physiological systems, it represents a therapeutic mechanism or class of interactions rather than a single, discrete drug target (Vizoso et al., 2017). Consequently, therapeutic development often focuses on the entire MSC secretome or specific components like exosomes to achieve these multi-receptor effects.

Other names

MSC secretome targetsMesenchymal stem cell paracrine signaling pathwaysMSC-mediated receptor modulation

MSCs act as "injury drugstores" by secreting a variety of paracrine factors (e.g., TGF-β, PGE2, IL-10, VEGF) that bind to specific endogenous receptors on host cells to modulate the immune response and promote tissue regeneration.