Multiple endogenous skin-regeneration pathways

Multiple endogenous skin-regeneration pathways encompass a network of signaling cascades, such as Wnt/beta-catenin, TGF-beta, and Notch, which are essential for maintaining skin homeostasis and orchestrating wound repair (PubMed: 23991006). These pathways regulate the activation of epidermal stem cells, the proliferation of keratinocytes, and the synthesis of extracellular matrix components by fibroblasts (StatPearls: NBK470443). In clinical practice, these pathways are targeted by agents like Becaplermin (recombinant PDGF) and retinoids to accelerate healing in chronic wounds or manage skin aging (NIH: PMC3840548). However, because this term refers to a collection of biological processes rather than a single protein or receptor, it is not classified as a discrete therapeutic target in the traditional sense. Therapeutic modulation must be carefully balanced, as overactivation can lead to fibrosis or increase the risk of skin malignancies (PubMed: 28258335).

Other names

Skin wound healing pathwaysCutaneous regeneration signalingEndogenous skin repair mechanisms

Activation of intracellular signaling cascades (e.g., Wnt, TGF-beta, Notch) to promote cellular proliferation, migration, and tissue remodeling.