Multiple endogenous wound-healing pathways

Multiple endogenous wound-healing pathways refers to the highly coordinated physiological processes—hemostasis, inflammation, proliferation, and remodeling—that restore tissue integrity after injury (StatPearls, 2023). These pathways involve the integrated action of various cell types, including platelets, neutrophils, macrophages, fibroblasts, and endothelial cells, which are regulated by a complex network of signaling molecules such as cytokines and growth factors (Journal of Clinical Investigation, 2014). In pathological conditions like diabetes or peripheral vascular disease, these endogenous pathways are often disrupted, leading to chronic, non-healing wounds (Nature Reviews Disease Primers, 2017). Therapeutic strategies targeting these pathways often involve the application of exogenous growth factors, such as Becaplermin (recombinant human PDGF), to stimulate cellular migration and proliferation (FDA, Regranex Label). Because this term encompasses a broad set of biological cascades rather than a single protein or receptor, it is classified as a physiological process rather than a discrete molecular target.

Other names

Wound healing cascadeTissue repair pathwaysEndogenous regenerative pathwaysPhases of wound healing

Therapeutic agents modulate these pathways by providing exogenous growth factors to stimulate cell migration and proliferation, or by managing the wound environment to transition from a chronic inflammatory state to a proliferative phase (PubMed, PMC3504384).