Multiple enzymes and receptors

The term 'Multiple enzymes and receptors' is a non-specific, aggregate classification rather than a distinct biological entity or therapeutic target. It is frequently employed in pharmacological literature to describe the activity of multi-target drugs, such as certain antipsychotics or multi-kinase inhibitors, which achieve therapeutic efficacy by modulating several proteins simultaneously (Nature Reviews Drug Discovery, 2004, 3:353-359). Because this term encompasses a broad and undefined set of molecules, it lacks a specific UniProt ID, structural motif, or singular biological pathway. In the context of drug discovery and target validation, this entry is considered 'incorrect' or 'too broad' as it does not allow for the precise characterization of molecular interactions or safety profiles (Nature Chemical Biology, 2008, 4:682-690). Effective therapeutic modeling and biotech analysis require the identification of the specific individual enzymes and receptors involved in a drug's mechanism of action to accurately assess efficacy and risk. This designation is often a result of incomplete target deconvolution or is used to describe substances with systemic, multi-modal effects.

Other names

Multi-targetPolypharmacological targets

Polypharmacological modulation of diverse protein classes