Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Multiple epidermal growth factor-like domains protein 10 (MEGF10)
- Target
- MEGF10
- Molecular classification
- Receptor, Membrane protein, Multiple EGF-like domains protein family
01
Overview
Multiple epidermal growth factor-like domains protein 10 (MEGF10) is a membrane receptor that binds to phosphatidylserine on apoptotic cells and mediates their phagocytosis, especially by macrophages and astrocytes[1][2][5]. It also promotes amyloid-beta peptide uptake in the brain and regulates myogenesis, impacting muscle cell adhesion, motility, and proliferation by interacting with Notch signaling pathways[1][2][6]. In the retina, MEGF10 helps establish mosaic spacing of interneurons. Mutations in MEGF10 can cause severe congenital myopathies (including EMARDD), and its expression has been linked to neuropsychiatric and neurodegenerative conditions[1][2].
- Other names
- Multiple EGF-like domains 10MEGF10KIAA1780Multiple EGF-like domains protein 10SR-F3CMYO10ACMYO10BCMYP10ACMYP10BEMARDD
02
Biological functions
Phagocytosis of apoptotic cellsAmyloid-beta uptakeCell adhesionCell motilityCell proliferationMyogenesis (muscle development and regeneration)Notch signaling regulationRetinal neuronal mosaic spacing
03
Disease associations
Early-onset myopathyEMARDD (early-onset myopathy, areflexia, respiratory distress, dysphagia)Congenital myopathy with minicoresSchizophrenia (association)Potential role in neurodegenerative diseases (amyloid-beta peptide uptake)
Beyond the preview
Go deeper on Multiple epidermal growth factor-like domains protein 10 (MEGF10).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Multiple epidermal growth factor-like domains protein 10 (MEGF10).