Multiple Helicobacter pylori proteins (H. pylori proteins)

Multiple Helicobacter pylori proteins represent the collective therapeutic targets within the Helicobacter pylori bacterium, a Gram-negative pathogen that colonizes the human gastric mucosa. Key targets within this group include urease, which neutralizes gastric acid to allow survival; penicillin-binding proteins (PBPs) involved in cell wall synthesis; the 30S and 50S ribosomal subunits responsible for protein translation; and DNA gyrase, which is essential for DNA replication. These proteins are the primary targets for standard triple and quadruple antibiotic therapies used to eradicate the infection. Helicobacter pylori is a major causative agent of chronic gastritis, peptic ulcers, and is classified as a Group 1 carcinogen due to its role in gastric cancer and MALT lymphoma. Effective targeting of these proteins is increasingly challenged by the global rise of multi-drug resistant strains, necessitating the development of novel inhibitors and vaccine candidates targeting specific virulence factors like CagA and VacA.

Other names

Helicobacter pylori proteomeH. pylori bacterial targetsHelicobacter pylori antigens

Inhibition of cell wall synthesis (beta-lactams), inhibition of protein synthesis (macrolides/tetracyclines), DNA strand breakage (nitroimidazoles), and inhibition of DNA gyrase (fluoroquinolones).