Multiple Helicobacter pylori surface and intracellular proteins (H. pylori proteins)

Helicobacter pylori proteins encompass a diverse array of surface-exposed and intracellular molecules essential for the bacterium's survival, colonization, and pathogenesis within the human gastric environment (StatPearls, 2023). Key surface proteins include urease, which neutralizes stomach acid by producing ammonia, and various adhesins like BabA and SabA that facilitate attachment to the gastric epithelium (Nature Reviews Microbiology, 2006). Intracellular targets include essential enzymes for DNA replication (DNA gyrase), protein synthesis (ribosomes), and cell wall assembly (penicillin-binding proteins), which are the primary focus of current antibiotic therapies (Journal of Clinical Medicine, 2020). Virulence factors such as CagA and VacA are also critical proteins that modulate host cell signaling and contribute to the development of gastric cancer and peptic ulcers (World Journal of Gastroenterology, 2014). Therapeutic strategies typically involve a combination of antibiotics and proton pump inhibitors to eradicate the infection by targeting multiple bacterial processes simultaneously (American College of Gastroenterology, 2017). The emergence of multi-drug resistant H. pylori strains remains a significant challenge in clinical management (Lancet Infectious Diseases, 2018).

Other names

Helicobacter pylori antigensH. pylori virulence factorsH. pylori proteomeH. pylori surface proteinsH. pylori intracellular proteins

Inhibition of cell wall synthesis (beta-lactams), inhibition of protein synthesis (macrolides, tetracyclines), inhibition of DNA synthesis (nitroimidazoles, fluoroquinolones), and neutralization of gastric acid (StatPearls, 2023).